NFL Week 6 early odds, betting lines: Buffalo Bills a slight favorite heading into showdown at Kansas City

Toss-up between Bears and Commanders will kick off the upcoming week

October 10, 2022 at 11:43 am CDT

Buffalo Bills fans cheer while playing the Los Angeles Rams during an NFL football game Thursday, Sept. 8, 2021, in Inglewood, Calif. (AP Photo/John McCoy)

Buffalo Bills fans cheer while playing the Los Angeles Rams during an NFL football game in Inglewood, Calif. (AP Photo/John McCoy) (John McCoy/AP)

One thing is for sure, Week 6 will be a tough one to prognosticate, as there are seven games with spread of three points or fewer, including the highlight game of Buffalo traveling to play their nemesis, the Kansas City Chiefs.

In that rematch of last year’s incredible AFC divisional-round playoff game, it’s the Bills, the Super Bowl LVII favorite, who are slight favorites heading into the week.

And if somehow you are still alive in your Survivor / Knockout pools, it could be a tough one, unless you still have the Los Angeles Rams available, as they are 10-point favorites over the Carolina Panthers, which fired Coach Matt Rhule on Monday morning.

Here’s the entire schedule, along with early lines from Caesars Sportsbook (as of Monday morning).

Bye weeks: Detroit, Houston, Las Vegas, Tennessee

Thursday, Oct. 13

Washington (even, ML -110, o/u 38.5) at Chicago (-110), 7:15 p.m.

Sunday, Oct. 16

New Orleans (+1, ML -105), o/u 43) vs. Cincinnati (-115), noon

Minnesota (-3, ML -155, o/u 45.5) at Miami (+130), noon

Baltimore (-5.5, ML -240, o/u 44) at NY Giants (+196), noon

New England (+3, ML +130, o/u 42.5) at Cleveland (-155), noon

San Francisco (-6, ML -267, o/u 43) at Atlanta (+215), noon

NY Jets (+7, ML +270, o/u 47) at Green Bay (-345), noon

[Go Full Caesar: Wager up to $1,250 for your first bet. If you don’t win, you’ll get 100% of your stake back as a Free Bet. And win or lose, you’ll also get 1,000 Reward Credits® and 1,000 Tier Credits]

Tampa Bay (-8, ML -385, o/u 43.5) at Pittsburgh (+300), noon

Jacksonville (+2, ML +115, o/u 42) at Indianapolis (-135), noon

Arizona (-3, ML -145, o/u 51.5) at Seattle (+122), 3:05 p.m.

Carolina (+10, ML +345, o/u 41) at LA Rams (-455), 3:05 p.m.

Buffalo (-2, ML -125, o/u 53.5) at Kansas City (+105), 3:25 p.m.

Dallas (+5, ML +192, o/u 42.5) at Philadelphia (-235), 7:20 p.m.

Monday, Oct. 17

Denver (+6, ML +215, o/u 45) at LA Chargers (-267), 7:15 p.m.

Must be 21 or older to gamble. Know When To Stop Before You Start.® If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537)

Jim Derry

Jim Derry is a sports betting writer for The Advocate